This suggested that cell/cell electrical and/or mechanical coupling was disrupted. Surprisingly, isolated left ventricular myocytes contracted normally and exhibited normal Ca 2+ transients. Four days later, we observed an 80% reduction in amplitude of the QRS complex, profound systolic dysfunction, decreased connexin43, loss of gap junctions, and abnormal intercalated discs. To determine the effect of increased integrin ligation and signaling on adult cardiac function, a heart-specific truncated α 5 integrin (gain of function) was conditionally expressed in mice. Integrins appear to be necessary for cardiac myocyte hypertrophy. Integrins mechanically link the cytoskeleton to the extracellular matrix in cardiac myocytes and are thereby involved in mechanotransduction. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.
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